Synthesis of IL-1b and TNF-a (Sironi et al., 1997; Ryu et al., 2007; Niscola et al., 2009). However, in the present study, benzydamine showed a weaker anti-inflammatory effect against IL-1b and TNF-a in comparison to OLE at two weeks after chemotherapy. This locating could recommend that OLE features a stronger anti-inflammatory action when compared with benzydamine. Inside the limitations on the study just like the quantity of sufferers, the study period, plus the randomization by computer block, these preliminary results indicate that additional studies are warranted to investigate the effects of OLE in decreasing cancerrelated complications.146 Conflict of interest None declared.K.M. AhmedHamdi, H.K., Castellon, R., 2005. Oleuropein, a non-toxic olive iridoid, is definitely an anti-tumor agent and cytoskeleton disruptor.Ir[dF(CF3)ppy]2(dtbbpy)PF6 Chemical name Biochem. Biophys. Res. Commun. 334, 769?78. Kim, J.H., Chu, F.C., Lakshmi, V., Houde, R., 1986. Benzydamine HCl, a new agent for the therapy of radiation mucositis with the oropharynx. Am. J. Clin. Oncol. (CCT) 9, 132?34. Lee-Huang, S., Huang, P.L., Zhang, D., Lee, J.W., Bao, J., Sun, Y., et al, 2007. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol. Biochem. Biophys. Res. Commun. 354, 872?84. Logan, R.M., Stringer, A.M., Bowen, J.M., Yeoh, A.S.-J., Gibson, R.J., Sonis, S.T., Keefe, D.M.K., 2007. The part of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: pathobiology, animal models and cytotoxic drugs. Cancer Treat. Rev. 33, 448?60. Logan, R., Stringer, A., Bowen, J., Gibson, R., Sonis, S., Keefe, D., 2009. Would be the pathobiology of chemotherapy-induced alimentary tract mucositis influenced by the type of mucotoxic drug administered? Cancer Chemother. Pharmacol. 63 (2), 239?51. Manna, C., Migliardi, V., Golino, P., Scognamiglio, A., Galletti, P., Chiariello, M., et al, 2004. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. J. Nutr. Biochem. 15, 461?66. Markin, D., Duek, L., Berdicevsky, I., 2003. In vitro antimicrobial activity of olive leaves. Mycoses 46, 132?36. Niscola, P., Scaramucci, L., Giovannini, M., Ales, M., Bondanini, F., Cupelli, L., et al, 2009. Palifermin within the management of mucositis in hematological malignancies: existing evidences and future perspectives. Cardiovasc. Hematol. Agents Med. Chem. 7, 305?12. Potting, C.M.J., Blijlevens, N.A.M., Donnelly, J.P., Feuth, T., Van Achterberg, T., 2006. A scoring system for the assessment of oral mucositis in each day nursing practice. Eur. J. Cancer Care 15 (three), 228?34. Prada, A., Chiesa, F., 1987. Effects of benzydamine on the oral mucositis for the duration of antineoplastic radiotherapy and/or intra-arterial chemotherapy.1932384-22-9 Chemscene Int.PMID:33503225 J. Tissue React. 9, 115?19. Raber-Durlacher, J.E., Elad, S., Barasch, A., 2010. Oral mucositis. Oral Oncol. 46, 452?56. Rodri?guez-Caballero, A., Torres-Lagares, D., Robles-Garci?a, M., ?????Pachon Iban, J., Gonzalez-Padilla, D., Gutierrez-Perez, J.L., 2012. Cancer treatment-induced oral mucositis: a essential assessment. Int. J. Oral Maxillofac. Surg. 41 (2), 225?38. Ryu, J.K., Swann, S., LeVeque, F., Scarantino, C.W., Johnson, D., Chen, A., et al, 2007. The influence of concurrent granulocyte macrophage-colony stimulating issue on radiation-induced mucositis in head and neck cancer sufferers: a double-blind placebocontrolled potential phase III study by radiation therapy oncology group. Int. J. Radiat. Oncol. Biol. Phys. 67 (three), 643?47. Silverman Jr, S., 2007. Diagnosis and management.