Product Name :
Rb Recombinant Rabbit Monoclonal Antibody [SY63-03]
Predicted band size :
106 kDa
Observed band size :
106 kDa
Synonyms:
Exon 17 tumor GOS561 substitution mutation causes premature stop antibody GOS563 exon 17 substitution mutation causes premature stop antibody OSRC antibody Osteosarcoma antibody p105-Rb antibody P105RB antibody PP105 antibody pp110 antibody PPP1R130 antibody pRb antibody 展开
Function :
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers. One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.2439223-60-4 Data Sheet Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer. The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.Imidazo[1,2-a]pyridine-8-carbaldehyde Data Sheet
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within mouse Rb aa 682-921 / 921.PMID:33487431
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP
Coupling :
unconjugated
Clone number:
SY63-03
RRID:
AB_3069784
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 106 kDa
Positive control :
Mouse lung tissue lysates, SW480, human spleen tissue, human breast carcinoma tissue, human colon tissue, human colon carcinoma tissue.