Product Name :
PPM1A Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Protein phosphatase 2C isoform alpha antibody EC 3.1.3.16 antibody FLJ42306 antibody IA antibody MGC9201 antibody Mpp alpha antibody PP2C alpha antibody PP2C-alpha antibody PP2CA antibody PP2Calpha antibody PPM 1A antibody 展开
Function :
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/ threonine protein phosphatases. Protein phosphatase 2Ca (PP2Ca) has broad specificity. It dephosphorylates and negatively regulates the activities of MAP kinases and MAP kinase-kinases while also inhibiting the activation of p38 and JNK kinase cascades, induced by environmental stresses. PP2Ca also induces the expression of endogenous p53 and the p53-responsive gene p21, leading to cell cycle arrest and apoptosis. The PP2Ca protein, which contains an active site containing a dinuclear metal ion center, shows highest expression in epithelial cells, as well as in the digestive tract, lung, kidney, breast, prostate, endocrine glands and brain.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Recombinant protein within Human PP2C alpha aa 42-330 / 382.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3069053
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.4-Bromo-1H,2H,3H-pyrrolo[2,3-b]pyridine custom synthesis Aliquot store at -20℃ or -80℃.1-(3-Aminopropyl)azepan-2-one web Avoid repeated freeze / thaw cycles.PMID:33634352
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
42/35 kDa, additional band 55 kDa
Positive control :
Mouse kidney tissue lysate, rat skin tissue lysate, A431, A549, SH-SY5Y, human kidney tissue, human colon cancer tissue, mouse intestine tissue.